Performace-wise, setting up Amazon CloudFront ("Custom Origin") in addition to WP Minify and WP Super Cache improved site response times a lot. Offloading static content to Amazon not only made those offloaded files load faster (because of Amazon's faster tubes) but this also reduced stress on our feeble-ish server on page load so that the document itself is returned faster. Load time is also more repeatable. Good stuff!
Note that CloudFront makes HTTP/1.0 requests and Apache may take some convincing in order to make it Gzip the 1.0 response.
Categorised as: meta